F2G (Group)

https://www.f2g.com

F2G is a world-leading UK- and Austria-based biotech company (F2G Ltd and F2G Biotech GmbH) focused on the discovery and development of novel therapies to treat life-threatening invasive fungal infections. F2G has discovered and developed a completely new class of antifungal agents called the orotomides. The orotomides selectively target fungal dihydroorotate dehydrogenase (DHODH), a key enzyme in the de novo pyrimidine biosynthesis pathway. This is a completely different mechanism from that of the currently marketed antifungal agents and gives the orotomides fungicidal activity against a broad range of rare and resistant fungal mold infections. Olorofim (formerly, F901318) is F2G’s leading candidate from this class and is in a Phase 2b open-label study focusing on rare and resistant invasive fungal infections such as aspergillosis (including azole-resistant strains), scedosporiosis (including lomentosporiosis). Olorofim has received orphan drug status from the European Medicines Agency for the treatment of invasive aspergillosis and invasive scedosporiosis. Olorofim has received orphan drug status from the US FDA for the treatment of coccidioidomycosis, lomentosporiosis/scedosporiosis, and invasive aspergillosis. Olorofim has been granted Qualified Infectious Disease Product (QIDP) designation Invasive for aspergillosis, invasive scedosporiosis, invasive lomentosporiosis, coccidioidomycosis, invasive disease due to Scopulariopsis species, and invasive fusariosis. *

	Start	2012-09-06 existent
	Today	F2G Ltd.
	Industry	antimycotic
	Industry 2	F901318 (F2G Ltd)
	Person	Lavino, Francesco Maria (F2G 202104– CEO before Nabriva Therapeutics + Merck (US) + Cubist Pharmaceuticals)
	Person 2	Vink, Patrick (Forbion 202007c– Operating Partner former COO of Cubist before Mylan + Sandoz)

	Region	Manchester, Greater Manchester
	Country	United Kingdom (GB)
	Street	Lankro Way Eccles
	City	M30 0LX Manchester
	Tel	+44-161-785-1270
		Address record changed: 2020-12-02

Basic data	Employees	n. a.

		* Document for »About Section«: F2G Ltd.. (4/12/21). "Press Release: Francesco Maria Lavino Appointed Chief Executive Officer of F2G Ltd". Manchester & Vienna.

		Record changed: 2023-07-10