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Financing › Details

Limula–SEVERAL: investment, 202405 seed financing round CHF6.2m led by LifeX Ventures


Period Period 2024-05-21
Organisations Money taker Limula SA
  Money source SEVERAL
Products Product cell and gene therapy manufacturing (CGT manufacturing)
  Product 2 venture capital
Person Person Berenguer, Inaki (LifeX Ventures 202311 Managing Partner)

Limula SA. (5/21/24). "Press Release: Limula Raises CHF 6.2 Million in Oversubscribed Seed Round to Develop Automated Cell and Gene Therapy Manufacturing Platform". Lausanne.

> Limula leverages ‘Swiss Made’ engineering and an experienced team to brings much-needed innovation to the field of Cell and Gene Therapy.

> Award-winning technology combines a bioreactor and a centrifuge into one single vessel for the first time, opening new avenues for manufacturing process automation.

> Limula is currently onboarding selected cell therapy developers to run pilots while financing will be used to further advance the development of the proprietary platform.

[photo] Limula founders: Luc Henry, CEO, Yann Pierson, CTO and Thomas Eaton, COO. Photograph CC-BY Jonathan Moy de Vitry

Over the last decade, several breakthrough Cell and Gene Therapy products have been approved in the USA and Europe to turn stem cells and immune cells into ‘living cures’, bringing hope to millions living with life-threatening conditions. However, these treatments remain out of reach for 98% of patients suffering from what are now curable conditions. This is in part due to complex, manual and costly manufacturing processes.

Life Science Tools company Limula announces today it has raised 6.2 million Swiss francs ($6.8 million) to take their solution for automating cell therapy manufacturing to the next stage of development. The oversubscribed seed round was led by LifeX Ventures, with participation from the founders, Verve Ventures, Zühlke Ventures, Oxford Seed Fund, Lichtsteiner Foundation, W.A. de Vigier Foundation, and a line-up of private individuals who have been supporting Limula’s vision from its inception.

The company was founded in 2020 by Dr. Yann Pierson, Dr Luc Henry. Dr. Thomas Eaton to deliver a disruptive approach to the ‘ex vivo’ manipulation of cells, based on a novel technology. The trio witnessed that outdated manufacturing methods were a speed bump to the adoption of Cell and Gene Therapy products – like chimeric antigen receptor (CAR) T-cells. Combining breakthrough discoveries in genetic engineering and medicine led to a revolution in medicine, but boosting the patients’ own cells to produce a dose in a laboratory still requires too many manual steps. Highly skilled labour and sterile infrastructures represent the majority of the costs of a therapy, leading to a price tag of $500,000 or more per dose. As a result, these treatments are inaccessible for a majority of eligible patients.

To combat this, Limula developed a modular solution for on-demand and at-scale manufacturing of cell therapies in a single device. By combining the functionalities of a bioreactor and a centrifuge into one single closed vessel, Limula’s proprietary solution can handle a wide range of volumes and cell numbers, removing transfer steps and therefore limiting stress, losses, and potential contamination. With a potential for scalability, it can be used by cell therapy providers in their transition from pre-clinical evaluation to clinical trials, and later commercial scale manufacturing of clinical-grade cell products.

Luc Henry, co-founder and CEO of Limula said: “Our team is driven by the ambitious goal of developing tools that are based on a fundamentally novel way of manipulating cells outside of the body. Our technology supports manufacturing workflows that are impossible to automate with existing tools. We believe automation is the only route to scalability and digital traceability. These two aspects are keys unlocking the full potential of Cell and Gene Therapy, making them accessible to the many, not just the few”.

Limula’s founders built a high performing multidisciplinary team, most recently joined by domain experts Olivier Waridel, former CEO of Cytiva-owned Biosafe, Caroline Boudousquié, former Head of Process Development at the Center for experimental therapeutics (CTE) of the University Hospital in Lausanne, and Maria Elena Grisostolo, former VP Operations at Lunaphore.

After completing an initial proof of concept, the company launched a program to provide selected industry and academic partners access to the innovative platform ahead of its commercial launch. With the aim to broaden the scope of applications, Limula has signed partnerships with several research centres including San Raffaele Telethon Institute for Gene Therapy in Milan, Italy – a world-recognized centre of excellence for research and clinical translation of cell and gene therapy.

Dr Inaki Berenguer, managing partner at LifeX Ventures said: “We’re thrilled to stand with the Limula team as they reinvent cell and gene therapy manufacturing. It’s evident that production tools have lagged behind scientific and clinical advancements, particularly in terms of price and scalability. Limula’s commitment to addressing these bottlenecks is crucial to enhancing accessibility for patients.”

Looking ahead, Limula will use its new Seed capital to significantly advance the development of the proprietary platform composed of a device and single use consumables, towards meeting good manufacturing practice (GMP) requirements. The solution developed by Limula is an enabling tool for a rapidly growing market. The potential of Cell and Gene Therapies to save the lives of millions of patients globally has generated significant interest – and investment – leading to a significant pipeline and several recent approvals by health authorities. Both industrial and academic players are now eager to adopt next-generation automated and scalable solutions with the shared goal to significantly increase market reach and broaden accessibility.

About Limula

Limula SA is a Life Science Tools company based in Lausanne, Switzerland, looking to disrupt the status quo in the manufacturing of Cell & Gene Therapies. Their mission is to support rapid and cost-effective introduction of new advanced therapy products to the market. Their cell processing platform leverages a proprietary design and automation to bring all functionalities required for on-demand and at-scale manufacturing of cell therapies in a single device.

About LifeX Ventures

LifeX Ventures is a New York-based venture capital firm investing in global visionary entrepreneurs using software and AI to develop transformational solutions that will extend the life of humans and the planet. With its $100M debut fund, LifeX is targeting the two largest sectors in the world: People (bio/health) and Planet (climate), where Software and AI suddenly matter.

About Verve Ventures

Verve Ventures is one of the most active venture investors in Europe with over 140 science and technology-driven startups in its portfolio. Verve Ventures’ dedicated team helps startups with their most pressing needs such as hiring, client introductions, and an expert network of high-profile individuals.

About Zühlke Ventures

Zühlke Ventures is an early stage venture capital investor with focus on HealthTech. Zühlke Ventures’s investment is paired with actionable expertise for finding product-market-fit, for developing and deploying novel products, and for entering international markets.

About Oxford Seed Fund

Oxford Seed Fund, run by the Entrepreneurship Centre at Saïd Business School is the largest student-led VC fund outside of North America, investing in top Oxford-affiliated technology enabled pre-seed and seed stage companies. Supporting them with access to funding, talent, skills and networks. The Fund deploys £600,000+ per year across 10+ companies.

About Lichtsteiner Foundation

The Lichtsteiner Foundation supports pioneers and early-stage startups in the field of health (medical technology, biotechnology, life science, mental health, public health and wellbeing) in order to improve people’s health in a sustainable way.

About W.A. de Vigier Foundation

Since the foundation’s establishment in 1987, the goal of the W.A. de Vigier Foundation has been to actively invigorate business development and further provide direct financial support to young people with innovative business ideas wishing to build performance and growth-oriented businesses in Switzerland. Until today, the W.A. de Vigier Foundation has awarded CHF 14.3 million in seed capital to Swiss startups.

Contact Details

Luc Henry, DPhil

Record changed: 2024-06-07


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